Unprecedented, highly convergent, high yielding, one-pot synthesis of phenylhydrazones 7, acylhydrazones 8 and thiosemicarbazones 9 (most of them obtained as Z-isomers) was carried out starting from 1,2,3 by in situ condensing isolable key intermediate iminium chlorides 4,5,1a 61b with nitrogen nucleophiles (R-NHNH2) in the presence of...
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2013 (v1)PublicationUploaded on: April 14, 2023
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2015 (v1)Publication
An unprecedented, highly convergent, high-yielding, one-pot synthesis of (acyl)hydrazones and thiosemicarbazones was carried out by the in situ condensation of isolable iminium chlorides of imidazolidin-2-(thio)one, tetrahydropyrimidin-2-thione and indole derivatives with nitrogen nucleophiles in the presence of a base. The developed reaction...
Uploaded on: April 14, 2023 -
2015 (v1)Publication
A new series of indole-based analogues were recently identified as potential anticancer agents. The Knoevenagel-type indoles herein presented were prepared via a one-pot condensation of iminium salts with active methylene reagents and were isolated as single geometric isomers. Biological evaluation in different cell-based assays revealed an...
Uploaded on: April 14, 2023