Two series of ()-2-phenyl-1-(quinolizidin-1α-yl)benzimidazoles, 12A–26A, and ()-2-phenyl-1- (quinolizidin-1β-yl)benzimidazoles, 12B–26B, were prepared and tested for the inhibition of human platelets aggregation induced by ADP, collagen, and adrenaline. All epimers A, i.e., 12A–26A, were devoid of any activity against the three agonists, while...
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2008 (v1)PublicationUploaded on: April 14, 2023
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2007 (v1)Publication
Eighteen analogues of lidocaine, mexiletine, and procainamide were synthesized, replacing their aminoalkyl chains with the rigid and cumbersome quinolizidine nucleus. The target compounds were tested for antiarrhythmic, inotropic, and chronotropic effects on isolated guinea pig (gp) heart tissues and to assess calcium antagonist activity. Most...
Uploaded on: April 14, 2023