Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible structural similaritywith endogenous ligands, most of the agonists developed so far resulted in being affected by a low selectivity for TAAR1 with respect to other...
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2023 (v1)PublicationUploaded on: February 14, 2024
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2022 (v1)Publication
Background: Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. Methods: We synthesized a small library of novel biguanide-based compounds that were...
Uploaded on: April 14, 2023