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2010 (v1)PublicationUploaded on: March 31, 2023
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2002 (v1)Publication
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Uploaded on: April 14, 2023 -
2004 (v1)Publication
Cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N4]-chloride platinum (II) monohydrochloride monohydrate (DPR) is a monofunctional Pt triamine complex synthesized starting from cisplatin and procaine hydrochloride, characterized by a good antitumor activity coupled with low toxic effects and able to impair prenatal development of...
Uploaded on: May 13, 2023 -
2000 (v1)Publication
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2006 (v1)Publication
Nanoparticles consisting of N-trimethyl chitosan (TMC) and alginate complexed with cisplatin were prepared. TMC a freely soluble quaternized derivative of chitosan with cell permeability properties, was synthesized by reductive methylation. The product was characterized by NMR spectroscopy to ascertain the degree of quaternization....
Uploaded on: March 31, 2023 -
2009 (v1)PublicationA novel nanoparticulate system based on a new cisplatin-hyaluronate complex and N-trimethyl chitosan
Nanoparticles with a positive surface charge were prepared through the electrostatic interaction of a new cisplatin-hyaluronate complex with N-trimethyl chitosan (substitution degree of 85%). With regard to the complex, which has been evaluated for its stability and anticancer activity, a critical comparison with other cisplatin-hyaluronate...
Uploaded on: April 14, 2023