MANERA , Valeria

Background: The use of Serious Games (SG) in the health domain is expanding. In the field of neuropsychiatric neurodegenerative disorders . SG are currently employed both to support and improve the assessment of different functional and cognitive abilities, and to provide alternative solutions for patients' stimulation, and rehabilitation. In...

International audience

Apathy is one of the most frequent behavioral disturbances in many neurodegenerative disorders and is known to have a negative impact on the disease progression, particularly in Alzheimer's disease. Therapeutic options are currently limited and non-pharmacological approaches should constitute first line treatments. Pharmacological agents likely...

International audience

International audience

BackgroundApathy is a syndrome that affects several dimensions of goal-directed behaviour, cognition, emotions and social interaction. There is a growing interest in understanding apathy and its association to the early stages of neurocognitive disorders such as Alzheimer's disease, Parkinson's disease, and frontotemporal dementia. This...

The aim of this study is to develop a generative and probabilistic statistical learning model for the joint analysis of heterogeneous biomedical data. The model will be applied to the investigation of neurological disorders from collections of brain imaging, body sensors, biological and clinical data available in current large-scale health...

The morphological changes affecting the brain over time are related to several biological processes, governed either by healthy aging or by pathological factors. Since these processes are to date largely unknown , we need statistical approaches to automatically identify these latent morphological evolutions through the analysis of structural...

International audience

International audience

International audience

Abstract Background Certain neuropsychiatric symptoms (NPS), namely apathy, depression, and anxiety demonstrated great value in predicting dementia progression, representing eventually an opportunity window for timely diagnosis and treatment. However, sensitive and objective markers of these symptoms are still missing. Therefore, the present...

Objective: Apathy is present in many brain disorders, but it is also prevalent to varying degrees in healthy people. While many tools have been developed to assess levels of apathy in pathology, no standardized measure of apathy in healthy people exists.Method: Therefore, this study aimed to validate the French version of the Apathy Motivation...