Alexander's disease (AxD) is a rare, usually relentlessly progressive disorder of astroglial cells in the central nervous system related to mutations in the gene encoding the type III intermediate filament protein, glial fibrillary acidic protein (GFAP). The pathophysiology of AxD is only partially understood. Available data indicate that an...
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2021 (v1)PublicationUploaded on: February 14, 2024
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2011 (v1)Publication
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2010 (v1)Publication
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2010 (v1)Publication
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Uploaded on: March 27, 2023 -
2010 (v1)Publication
Alexander disease is a rare, untreatable and usually fatal neurodegenerative disorder caused by heterozygous mutations of the glial fibrillary acidic protein (GFAP) gene which ultimately lead to formation of aggregates, containing also ?B-Crystallin, HSP27, ubiquitin and proteasome components. Recent findings indicate that up-regulation of...
Uploaded on: April 14, 2023