El cerebro de pacientes enfermos de Alzheimer acumula marcadores angiogénicos, sin embargo, paradójicamente, la microvasculatura cerebral está reducida alrededor de las placas de Aβ. En este trabajo hemos demostrado que la angiogénesis se induce en las proximidades de los depósitos amiloides, tanto en modelos murinos, como en pacientes de...
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December 2, 2021 (v1)PublicationUploaded on: December 4, 2022
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July 30, 2024 (v1)Publication
Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related to oxidative phosphorylation system (OXPHOS) defects in neurons. Interestingly, both PMD mouse models and patients with PMD show gliosis, and pharmacological depletion of microglia, the innate immune cells of the brain,...
Uploaded on: July 31, 2024