A. MARTINES

The calpain/calpastatin proteolytic system regulates several physiopathological processes and can play opposing roles in cancer. New strategies to control alterations ofthis system for therapeutic purposes require a full understanding of the functional role played by the single protein members. For this purpose we have evaluated theinvolvement...

In this study we show that molecules extracted from olive pomace prevent cell death induced by Ca2+­overloading.Exposure of human neuroblastoma SKNBE, mouse brain endothelioma bEnd5 and human peripheral blood mononuclearcells to these molecules counteracts the Ca2+­induced cell damages by reducing the activation of the Ca2+­dependentprotease...

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