ACQUARONE , Erica

Background: Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory, therefore representing a critical hallmark in the etiopathogenesis of Alzheimer's disease. However, the molecular mechanisms underlying the Synaptic and memory dysfunction induced by elevation of oTau...

From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been...