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ALFEI , Silvana

Last name: ALFEI

First name: Silvana

2017 (v1)

Publication

Metadata-only

An optimized and very detailed, grams scale synthesis of CTEP, through a complete characterization of all the isolated and purified intermediates

ALFEI, SILVANA Baig, Irum

Glutamate is the major excitatory neurotransmitter in the brain. 2-Chloro-4-[2,5-dimethyl-1-(4-trifluoromethoxyphenyl)-1H-imidazol-4-ylethynyl]pyridine (5) (CTEP) is the first reported negative allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5NAM) with a biological half-life of 48 hours in rodents and therefore considered an...

Uploaded on: March 27, 2023