ANZALDI , Maria

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A series of N-substituted pyrazole derivatives have been synthesized and tested for their anticancer effect on the HL-60 leukaemia cell line. Four were active both in cell-growth inhibition and in inducing apoptosis. The inhibition of cell growth mainly reflects a compound-induced reduction in the number of cells in phases from S to M, whereas...

Five- and six-membered heterocyclic ionone-like derivatives 4-6 have been synthesised in one step and with good yield from the key intermediate 3a and appropriate bifunctional reagents. Four were active as inhibitors of the respiratory burst of human neutrophils without affecting cell viability. The two most active compounds (5a,d) tested in...

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The phenylhydrazone RDR-1 is endowed with moderate activity as F508del-CFTR corrector; nevertheless, its simple structure enables stimulating developments in this class of correctors. Therefore, we synthesized a number of phenylhydrazones 3 by reacting phenylhydrazine derivatives 1 with furfural derivatives 2. By the same reaction, also the...

New compds. having tri- or penta-methylenamine linker functions were synthesized.  These derivs. were covalently attached through the 5'-phosphoramide linkage to heptanucleotide pd(CCAAACA).  Complementary complexes of the octa-nucleotide pd(TGTTTGGC) and above oligonucleotide conjugates were tested for their thermodn. response.  The Tm data...

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