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2005 (v1)PublicationUploaded on: April 14, 2023
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2003 (v1)Publication
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1995 (v1)Publication
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Uploaded on: December 5, 2022 -
2005 (v1)Publication
Somatostatin receptors and glutamate NMDA receptors coexist and interact in hippocampal noradrenergic axon terminals. Activation of somatostatin receptors was previously found to positively influence the function of NMDA receptors regulating norepinephrine release. The somatostatin receptors involved were pharmacologicaaly characerized as sst...
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2003 (v1)Publication
SS analogs may be of interest in the treatment of lymphoproliferative malignancies, although controlled studies are warranted to investigate the efficacy of the current available analogs. A promising approach in refractory patients with SSR positive malignant lymphomas may be radionuclide-targeted therapy. Furthermore, the development of...
Uploaded on: March 25, 2023 -
2013 (v1)Publication
The actions of somatostatin (SRIF) are mediated by specific G protein-coupled receptors, named SRIF receptor (SSTR) subtypes 1, 2, 3 and 5. SRIF binding to SSTR activates a series of second messenger systems, resulting in the inhibition of calcium channels and adenylate cyclase activity, ultimately leading to inhibition of hormone secretion,...
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2010 (v1)Publication
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1998 (v1)Publication
The production by the liver of the three subunits of the growth hormone (GH)-dependent 150 kDa complex (IGF-I, IGF-binding protein-3 and acid-labile subunit or ALS) is primarily under the control of GH. Recent data have shown that, besides GH, endotoxin (LPS) and cytokines may regulate the liver IGF-I gene. To investigate the potential...
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2014 (v1)Publication
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2012 (v1)Publication
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1999 (v1)Publication
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2009 (v1)Publication
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Uploaded on: March 31, 2023 -
2003 (v1)Publication
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2007 (v1)Publication
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1997 (v1)Publication
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2012 (v1)Publication
The objective of this study is to assess the secretory pattern of GH after Oral Glucose Tolerance Test (OGTT) or day-curve (DC), in relation with IGF-I and to evaluate the influence of therapy on OGTT. A retrospective analysis in 279 OGTTs performed in 93 acromegalic patients in our unit from January 1988 to December 2005, in 77 patients also...
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2009 (v1)Publication
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2007 (v1)Publication
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2004 (v1)Publication
OBJECTIVE: It has been suggested that the threshold of 1 micro g/l of GH nadir after glucose load for definition of controlled acromegalic disease proposed in the 2000 consensus statement should be lowered to 0.30. We evaluated these two cut-off values in comparison with IGF-I, ALS and IGFBP-3 in a group of acromegalic patients. With the aim...
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2009 (v1)PublicationEffect of environment on growth: auxological and hormonal parameters in African and Italian children
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1996 (v1)Publication
As it has been hypothesized that IGF-binding proteins (IGFBPs) may have a role as autocrine/paracrine factors in regulating the local actions of the insulin-like growth factors (IGFs) in the ovary, we studied the production of the IGFBPs by human granulosa cells (GC) in culture and the role of IGFBP-3 in the modulation of ovarian cell...
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2016 (v1)Publication
Insulin-like growth factor type II (IGF-II) is the main cause of non-islet cell tumour hypoglycaemia (NICTH) and insulin is thought to be the only factor causing hypoglycaemia in insulinomas. However, two case reports of pancreatic neuroendocrine tumours (PNETs) producing IGF-II have been previously published: a human and a canine patient. In...
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2012 (v1)Publication
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2010 (v1)Publication
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Uploaded on: April 14, 2023