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ABBRUZZESE , Claudia

Last name: ABBRUZZESE

First name: Claudia

2017 (v1)

Publication

Metadata-only

The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme

Abbruzzese, Claudia Catalogna, Giada Gallo, Enzo

Glioblastoma multiforme (GBM) is the deadliest brain tumor. State-of-art GBM therapy often fails to ensure control of a disease characterized by high frequency of recurrences and progression. In search for novel therapeutic approaches, we assayed the effect of compounds from a cancer drug library on the ADF GBM cell line, establishing their...

Uploaded on: April 14, 2023
2016 (v1)

Publication

Metadata-only

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

Talarico, Cristina Dattilo, Vincenzo D'Antona, Lucia

Glioblastoma multiforme (GBM) is the most aggressive CNS tumor and is characterized by a very high frequency of clinical relapse after therapy and thus by a dismal prognosis, which strongly compromises patients survival. We have recently identified the small molecule SI113, as a potent and selective inhibitor of SGK1, a serine/threonine protein...

Uploaded on: April 14, 2023