ABI NADER , Clément

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by biological and morphological processes which spread over decades, ultimately leading to cognitive and behavioral decline. These processes can be monitored thanks to biomarkers and imaging measurements. As the mechanisms underlying the evolution of the pathology remain...

In this study we investigate a novel quantitative instrument for the development of intervention strategies for disease modifying drugs in Alzheimer's disease. Our framework is based on the modeling of the spatio-temporal dynamics governing the joint evolution of imaging and clinical biomarkers along the history of the disease, and allows the...

SimulAD is a computational disease progression model (DPM) originally developed on the ADNI database to simulate the evolution of clinical and imaging markers characteristic of AD, and to quantify the disease severity (DS) of a subject. In this work, we assessed the validity of this estimated DS, as well as the generalization of the DPM, by...