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AGUS , Allison

Last name: AGUS

First name: Allison

February 3, 2015 (v1)

Journal article

Metadata-only

Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation

Denizot, Jérémy Desrichard, Alexis Agus, Allison

Objective Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC strains adhere to enterocytes via interaction between type 1 pili and CEACAM6 receptors abnormally expressed on CD ileal mucosa, leading to gut inflammation. We analysed whether epigenetic mechanisms are involved in the...

Uploaded on: December 4, 2022
2016 (v1)

Journal article

Metadata-only

Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

Agus, Allison Denizot, Jérémy Thevenot, Jonathan

Recent advances have shown that the abnormal inflammatory response observed in CD involves an interplay among intestinal microbiota, host genetics and environmental factors. The escalating consumption of fat and sugar in Western countries parallels an increased incidence of CD during the latter 20 th century. The impact of a HF/HS diet in mice...

Uploaded on: December 4, 2022