La respuesta inmune es dividida en inmunidad innata e inmunidad adquirida. Una particularidad del sistema inmune, respecto del resto de órganos y sistemas anatómico-funcionales, es que no está estructurado en forma de tejidos fijos y bien localizados, sino que se caracteriza por la continua movilidad de los elementos celulares que los integran,...
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December 10, 2015 (v1)PublicationUploaded on: December 5, 2022
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November 15, 2022 (v1)Publication
Non-alcoholic fatty liver disease (NAFLD), which affects about a quarter of the global population, poses a substantial health and economic burden in all countries, yet there is no approved pharmacotherapy to treat this entity, nor well-established strategies for its diagnosis. Its prevalence has been rapidly driven by increased physical...
Uploaded on: December 4, 2022 -
November 17, 2022 (v1)Publication
Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine secreted by adipose tissue that increases in obesity and has central actions not only at the hypothalamic level but also in other regions and nuclei of the central...
Uploaded on: December 2, 2022 -
March 1, 2024 (v1)Publication
Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process and present antigens to activate naïve T cells and originate favorable immune responses in many diseases, such as cancer. However, in the last...
Uploaded on: March 3, 2024 -
May 31, 2016 (v1)Publication
Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play important roles in controlling cholesterol homeostasis and as regulators of inflammatory gene expression and innate immunity, by blunting the induction of classical pro-inflammatory genes. However, opposite data have also been...
Uploaded on: March 27, 2023 -
July 11, 2024 (v1)Publication
Obesity is frequently accompanied by non-alcoholic fatty liver disease (NAFLD). These two diseases are associated with altered lipid metabolism, in which reverse cholesterol transport (LXRα/ABCA1/ABCG1) and leptin response (leptin receptor (Ob-Rb)/Sam68) are involved. The two pathways were evaluated in peripheral blood mononuclear cells (PBMCs)...
Uploaded on: July 12, 2024 -
February 22, 2024 (v1)Publication
Background: Sulforaphane (SFN) is an isothiocyanate of vegetable origin with potent antioxidant and immunomodulatory properties. The characterization of its pleiotropic activity in human dendritic cells (DCs) is poorly summarized. The aim of this work was to study the immunomodulatory power of SFN in response to an inflammatory microenvironment...
Uploaded on: February 24, 2024 -
February 23, 2024 (v1)Publication
Cancer is a complex disease that, despite advances in treatment and the greater understanding of the tumor biology until today, continues to be a prevalent and lethal disease. Chemotherapy, radiotherapy, and surgery are the conventional treatments, which have increased the survival for cancer patients. However, the complexity of this disease...
Uploaded on: February 25, 2024 -
December 15, 2020 (v1)Publication
Pluripotent stem cells maintain the property of self-renewal and differentiate into all cell types under clear environments. Though the gene regulatory mechanism for pluripotency has been investigated in recent years, it is still not completely understood. Here, we show several signaling pathways involved in the maintenance of pluripotency. To...
Uploaded on: March 25, 2023 -
June 13, 2023 (v1)Publication
Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these functional foods can interact with the immune system by modulating or balancing the exacerbated proinflammatory response. In this process, immune cells, such as antigen-presenting cells...
Uploaded on: June 15, 2023 -
September 14, 2023 (v1)Publication
In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible...
Uploaded on: October 18, 2023 -
February 22, 2024 (v1)Publication
Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens. Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines, and...
Uploaded on: February 24, 2024 -
February 22, 2024 (v1)Publication
The defense mechanism against harmful stimuli is inflammation. Indeed, neurodegenerative disorders can arise as a result of a persistent neuroinflammation. Beta-amyloid (Aβ1-42) is an early trigger in the origination of Alzheimer's disease, leading to synaptic and cognitive impairments. Virgin olive oil (VOO) is correlated with a decreased risk...
Uploaded on: February 24, 2024 -
June 16, 2023 (v1)Publication
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Uploaded on: June 17, 2023