ALCUDIA CRUZ , Ana

Nos propusimos como objetivos de esta memoria los siguientes:1) Síntesis estereoselectivas de N- sulfiniliminas con distintos sustituyentes en el azufre sulfinílico, con ... La síntesis de N- sulfiniliminas α,β-insaturadas, estaba encaminado al estudio de la competencia de los procesos de ciclopropanación y aziridinización en la reacción de...

Procedimiento para la preparación de fosfinas y óxidos de fosfinas quirales a partir de fosfinatos de di-O-aquiliden y di-O- ariliden-α-D-glucofuranosilo. El objeto de la presente invención es un procedimiento para la preparación de compuestos de fósforo quirales, fundamentalmente fosfinas y ´óxidos de fosfinas, seg´un un procedimiento de...

Las nuevas normativas que la Legislación impone relativas a los hábitos saludables y de seguridad que deben cumplirse en los laboratorios, han supuesto una revolución muy positiva en estos entornos de trabajo. Estos cambios están siendo posibles, gracias a la introducción de mejores infraestructuras, que están posibilitando al investigador la...

An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. The method is based on a beneficial effect of catalytic DMAP, which enhances both the rate of the reaction and the enantioselectivity of the process to give (R S)-diastereomer 2 R S with a 94 % de and in quantitative yield. (R...

Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. For example, the development of novel drug delivery systems in the form of nanoparticles is improving the liberation, absorption, distribution, metabolism, and excretion...

Porous titanium substrates coated by dripping-sedimentation technique with a novel bilayer of (45S5 / 1393) bioactive glasses are proposed to overcome some limitations of the use of titanium for implants, such as the stress shielding and the poor osseointegration. Composition, thickness, roughness and micromechanical behavior (P-h curves) of...

Articular cartilage (AC) has a low ability for endogenous repair, and current treatments are not completely efficient in generating strong and healthy repair tissue. As a result, there is a great deal of interest in cartilage repair and recovery of joint function due to the aging population and the increasing frequency of cartilage degradation...

Porous substrates of commercially pure titanium have been coated with a novel bilayer of bioactive glasses, 45S5 and 1393, to improve the osseointegration and solve the stress-shielding phenomenon of titanium partial implants. The porosity of the substrates, the scratch resistance and bioactivity of the coating have been evaluated. Results are...

Nowadays there is a worldwide growing interest in the Inkjet Printing technology owing to its potentially high levels of geometrical complexity, personalization and resolution. There is also social concern about usage, disposal and accumulation of plastic materials. In this work, it is shown that sugar-based biodegradable polyurethane polymers...

Despite the increasing progress achieved in the last 20 years in both the fabrication of porous dental implants and the development of new biopolymers for targeting drug therapy, there are important issues such as bone resorption, poor osseointegration, and bacterial infections that remain as critical challenges to avoid clinical failure...

An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry...

The present work describes the preparation of stable organic nanoparticles with potential use as "smart" drug delivery systems capable of encapsulating lipophilic molecules to exert their therapeutic action under the appropriate stimulus. A well-defined self-assembly hydrophilichydrophobic di-block copolymer has been synthesized via atom...

Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl hydrazones, the nature of the spacer and the substituent at the sulfinyl sulfur are key elements for the enantioselectivity of the process.

Stress shielding phenomenon, poor osseointegration, or bacterial infections of titanium dental implants are widely recognized as key problems that deeply affect their survival rate. In this work, a joint solution to solve these three limitations is proposed. The first two issues were minimized applying porous Ti samples. This substrate exhibits...

In this study, the best equilibrium among adherence, micro-mechanical properties and coating bioactivity of bioactive glasses (45S5 and 1393) on porous titanium substrates has been explored and their potential uses for bone tissue implants. Porous titanium discs with different porosities (30 and 60 vol.%) and pore size distributions (100–200...

This work discloses an epidemiological mathematical model to predict an empirical treatment for dogs infected by Pseudomonas aeruginosa. This dangerous pathogen is one of the leading causes of multi-resistant infections and can be transmitted from dogs to humans. Numerical simulations and appropriated codes were developed using Matlab software...

The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption of the bone surrounding the implant and improve osseointegration, respectively. However, the presence of pores as well as the poor adherence and the brittle behavior inherent to glassy coatings...