ALDINUCCI M.

Energy consumption is one of the major issues in today's computer science, and an increasing number of scientific communities are interested in evaluating the tradeoff between time-to-solution and energy-to-solution. Despite, in the last two decades, computing which revolved around centralized computing infrastructures, such as supercomputing...

Background: High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of DNA interactions and 3D chromosome folding at the genome-wide scale. Usually, these data are represented as matrices describing the binary contacts among the different chromosome regions. On the other hand, a graph-based representation can be...

Many bioinformatic applications require to exploit the capabilities of several computational resources to effectively access and process large and distributed datasets. In this context, Grid computing has been largely used to face unprecedented challenges in Computational Biology, at the cost of complex workarounds needed to make applications...

High-Performance Computing (HPC) is one of the strategic priorities for research and innovation worldwide due to its relevance for industrial and scientific applications. We envision HPC as composed of three pillars: infrastructures, applications, and key technologies and tools. While infrastructures are by construction centralized in...