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ALEPUZ , Paula M.

Last name: ALEPUZ

First name: Paula M.

February 22, 2018 (v1)

Publication

Metadata-only

A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region

Jimeno González, Silvia Gómez Herreros, Fernando Alepuz, Paula M.

The FACT complex stimulates transcription elongation on nucleosomal templates. In vivo experiments also involve FACT in the reassembly of nucleosomes traversed by RNA polymerase II. Since several features of chromatin organization vary throughout the genome, we wondered whether FACT is equally required for all genes. We show in this study that...

Uploaded on: December 4, 2022
September 30, 2021 (v1)

Publication

Metadata-only

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration

Begley, Victoria Sarah Jordán Pla, Antonio Peñate Salas, Xenia

mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce...

Uploaded on: December 4, 2022