L-arginine is often covalently linked to delivery systems for increasing their transfection activity and reducing toxicity and its basic nitrogen atoms need protection for example with tert-butoxycarbonyl group. Following three reported protocols which assured the goal of obtaining the widely cited...
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2018 (v1)PublicationUploaded on: April 14, 2023
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2024 (v1)Publication
The increasing emergence of multidrug resistant (MDR) pathogens, due to antibiotics misuse, leads to obstinate infections, with high morbidity and high-cost hospitalizations. To oppose these MDR superbugs, new antimicrobial options are necessary. Quaternary phosphonium salts (QPSs) have demonstrated appealing antibacterial properties, and a...
Uploaded on: August 30, 2024 -
2018 (v1)Publication
L-arginine, nowadays, is more and more used to functionalize scaffolds for producing delivery systems with high transfection activity and low toxicity. For these purposes it is better to be protected to basic nitrogen atoms. A well known protective residue is tert-butoxycarbonyl group (BOC) and three protocols of BOC-protection selected by us...
Uploaded on: April 14, 2023 -
2022 (v1)Publication
Water-soluble formulations of the pyrazole derivative 3-(4-chlorophenyl)-5-(4-nitrophenylamino)-1H-pyrazole-4-carbonitrile (CR232), which were proven to have in vitro antiproliferative effects on different cancer cell lines, were prepared by two diverse nanotechnological approaches. Importantly, without using harmful organic solvents or...
Uploaded on: April 14, 2023 -
2021 (v1)Publication
The genus Acinetobacter consists of Gram‐negative obligate aerobic pathogens, including clinically relevant species, such as A. baumannii, which frequently cause hospital infections, affecting debilitated patients. The growing resistance to antimicrobial therapies shown by A. baumannii is reaching unacceptable levels in clinical practice, and...
Uploaded on: April 14, 2023 -
2021 (v1)Publication
Memory and cognitive functions depend on the cerebral levels of cyclic adenosine monophosphate (cAMP), which are regulated by the phosphodiesterase 4 (PDE4) family of enzymes. Selected rolipram-related PDE4 inhibitors, members of the GEBR library, have been shown to increase hippocampal cAMP levels, providing pro-cognitive benefits with a safe...
Uploaded on: April 14, 2023