ALICE BALBONI

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Neuroblastoma is an embryonal tumour originating from the simpatico-adrenal lineage of the neural crest. It approximately accounts for about 15% of all paediatric oncology deaths. Metastatic Neuroblastoma tumours at diagnosis remains a clinical challenge, despite advances in multimodal therapy. Retinoids are a class of compounds known to induce...

D--tocopheryl polyethylene glycol succinate 1000 (TPGS) represents a vitamin E-based water-soluble molecule, which is synthetized from the natural vitamin E esterified with succinic acid and then the obtained vitamin E succinate derivative is linked to polyethylene glycol 1000 (PEG). Also due to its natural origin, TPGS is a safe amphiphilic...

Traditionally, cell cultures have been performed on 2-dimensional surfaces, but recent evidences have demonstrated that 2D-cultured cells are morphologically different from natural cells, which may induce alterations in cellular biochemical processes and trafficking. On the contrary, in a 3D culture, cells retain their shape and the relevant...

Extracellular vesicles (EVs) are emerging as interesting theranostic tools, presenting features that make them feasible drug delivery systems. However, the application of EVs in drug delivery is hampered by several issues like the high heterogeneity and batch-to-batch variation caused by the lack of efficient GMP protocols, possible...

The majority of anticancer agents currently used derive from natural sources: plants, frequently the ones employed in traditional medicines, are an abundant source of mono- and diterpenes, polyphenols, and alkaloids that exert antitumor activity through diverse mechanisms. Unfortunately, many of these molecules are affected by poor...

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Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate...

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Inflammation is a physiological response to a damaging stimulus but sometimes can be the cause of the onset of neurodegenerative diseases, atherosclerosis, and cancer. These pathologies are characterized by the overexpression of inflammatory markers like endothelial adhesion molecules, such as Vascular Cell Adhesion Molecule-1 (VCAM-1). In the...

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