Debido al aumento de la esperanza de vida, existe cada vez una mayor prevalencia de enfermedades neurodegerativas que, junto con su frecuente etiología desconocida, puede llegar a ser un problema socioeconómico y sanitario de alta importancia. Por ello, todos los esfuerzos actuales se están centrando en la búsqueda de dianas biológicas que...
-
January 30, 2023 (v1)PublicationUploaded on: February 22, 2023
-
September 28, 2017 (v1)Publication
Caspase8 "knock out" - Embryo development- Dual role La apoptosis o muerte celular inducida es un proceso de muerte fisiológica implicado en numerosos eventos relacionados con el desarrollo, la homeostasis de tejidos, la educación de células, e incluso el envejecimiento. Juega un papel tan esencial en el organismo que un desequilibrio positivo...
Uploaded on: March 26, 2023 -
November 25, 2019 (v1)Publication
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions. In this mini review, we focus on the most recent "non-apoptotic" roles of caspases in the CNS, particularly in neurons, astrocytes and...
Uploaded on: March 26, 2023 -
September 24, 2020 (v1)Publication
Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than 150 different types of NMDs, where the common feature is the loss of muscle strength. These disorders are classified according to their neuroanatomical location, as motor neuron diseases, peripheral nerve diseases, neuromuscular junction diseases, and muscle...
Uploaded on: March 27, 2023 -
March 24, 2020 (v1)Publication
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson'sdisease(PD),andseemstoplayakeyroleintheirdevelopmentandprogression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means they are able to have anti-inflammatory, pro-inflammatory, or...
Uploaded on: March 27, 2023 -
May 25, 2023 (v1)Publication
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+ microglia)...
Uploaded on: May 26, 2023 -
May 7, 2021 (v1)Publication
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the globe causing coronavirus disease 2019 (COVID-19). Because it affects the respiratory system, common symptoms are cough and breathing difficulties with fever and fatigue. Also, some cases progress to acute respiratory distress syndrome (ARDS). The acute phase...
Uploaded on: March 25, 2023 -
June 23, 2023 (v1)Publication
Adult hippocampal neurogenesis (AHN) is a process involved in numerous neurodegenerative diseases. Many researchers have described microglia as a key component in regulating the formation and migration of new neurons along the rostral migratory stream. Caspase-3 is a cysteine-aspartate-protease classically considered as one of the main effector...
Uploaded on: June 24, 2023