AMERI P

Recent epidemiological analyses suggest that incident cancer may be more common among patients with preexisting heart failure (HF) than in patients without HF. Arguments against this notion have been the increased chance of co-occurrence of 2 high-prevalence conditions and increased tumor detection in patients with HF because of intensified...

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Indoxyl sulphate (IS) accumulates during chronic kidney disease (CKD) leading to CKD- related myocardial fibrosis. We previously reported that IS activates cardiac fibroblasts (Fib) to a fibrotic/inflammatory phenotype [Ruggeri C, SIRC 2018]. Previous authors proposed the inhibition of Aryl hydrocarbon Receptor (AhR) activity to counteract IS...