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AMUNDADOTTIR , Laufey

Last name: AMUNDADOTTIR

First name: Laufey

September 2003 (v1)

Journal article

Metadata-only

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.

Ghiglione, Christian Amundadottir, Laufey Andresdottir, Margret

The transmembrane protein Kekkon 1 (Kek1) has previously been shown to act in a negative feedback loop to downregulate the Drosophila Epidermal Growth Factor Receptor (DER) during oogenesis. We show that this protein plays a similar role in other DER-mediated developmental processes. Structure-function analysis reveals that the extracellular...

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