ANDOLFI , Andrea

The aim of this work was to demonstrate chitosan micropatterning effectiveness to realize spatially guided 2D neuronal networks of primary rat neurons and neurons derived from human induced pluripotent stem cells (h-iNeurons). Morphological characterizations were carried out to validate the formation of a well-defined neuronal networks.

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: Understanding how the spatial organization of a neural network affects its activity represents a leading issue in neuroscience. Thanks to their accessibility and easy handling, in vitro studies remain an essential tool to investigate the relationship between the structure and function of a neuronal network. Among all the patterning...