ANDREOTTI F

Inflammation and genetics are both prominent mechanisms in the pathogenesis of atherosclerosis and arterial thrombosis. Accordingly, a number of population studies have explored the association of ischaemic heart disease with gene polymorphisms of the inflammatory molecules tumour necrosis factors (TNF) alpha. and beta, transforming growth...

No description

After acute coronary syndromes,the beneficial effect of aspirin plus clopidogrel (A + C) or aspirin plus dose-adjusted warfarin (A + W) compared with aspirin alone is well established. However, these regimens were never compared. To compare the risk-benefit profile of A + C versus A + W after acute coronary syndromes, major medical databases...

No description

No description

Object: Pexelizumab is a humanized monoclonal antibody inhibiting C5 complement. It has been postulated to improve outcomes in patients undergoing coronary artery bypass surgery and urgent reperfusion therapy for ST elevation myocardial infarction. We aimed at evaluating the risk/benefit profile of pexelizumab (bolus 1 infusion) versus placebo...

No description

Background Subgroup analyses of trials enrolling acute coronary syndrome patients suggest that inhibition of glycoprotein IIb/IIIa can improve the outcome of diabetic patients undergoing percutaneous coronary interventions (PCIs), possibly by improving microvascular perfusion. However, the efficacy of small-molecule IIb/IIIa receptor inhibitors...

No description

No description