: Kidney disease is a global health and healthcare burden. Glomerulonephritis (Gn), both primary and secondary, is generally characterized by an inflammatory glomerular injury and may lead to end-stage renal disease. Kidney biopsy is fundamental to the diagnosis; however, kidney biopsy presents some concerns that may partly hamper the clinical...
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2023 (v1)PublicationUploaded on: February 14, 2024
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2023 (v1)Publication
: Kidney disease is a global health and healthcare burden. Glomerulonephritis (Gn), both primary and secondary, is generally characterized by an inflammatory glomerular injury and may lead to end-stage renal disease. Kidney biopsy is fundamental to the diagnosis; however, kidney biopsy presents some concerns that may partly hamper the clinical...
Uploaded on: February 14, 2024 -
2022 (v1)Publication
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Uploaded on: February 14, 2024 -
2024 (v1)Publication
: Focal segmental glomerulosclerosis (FSGS) is one of the leading causes of kidney failure and it is characterized by a high rate of recurrence after kidney transplant. Moreover, FSGS recurrence is worsened by an increased risk of graft failure. Common therapies for FSGS recurrence mostly consist of plasma exchange treatments, also for...
Uploaded on: July 3, 2024 -
2023 (v1)Publication
: Nephrotic syndrome affects about 2-7 per 100,000 children yearly and accounts for less than 15% of end stage kidney disease. Steroids still represent the cornerstone of therapy achieving remission in 75-90% of the cases The remaining part result as steroid resistant nephrotic syndrome, characterized by the elevated risk of developing end...
Uploaded on: February 14, 2024 -
2023 (v1)Publication
Glomerulonephritis are renal disorders resulting from different pathogenic mechanisms (i.e., autoimmunity, complement, inflammatory activation, etc.). Clarifying details of the pathogenic cascade is basic to limit the progression from starting inflammation to degenerative stages. The balance between tissue injury, activation of protective...
Uploaded on: January 31, 2024 -
2022 (v1)Publication
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Uploaded on: February 4, 2024 -
2024 (v1)Publication
Research on membranous nephropathy truly exploded in the last 15 years. This happened because of the application of new techniques (laser capture microdissection, mass spectrometry, protein G immunoprecipitation, arrays) to the study of its pathogenesis. After the discovery of PLA2R as the major target antigen, many other antigens were...
Uploaded on: July 3, 2024 -
2023 (v1)Publication
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Uploaded on: February 6, 2024 -
2023 (v1)Publication
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Uploaded on: February 6, 2024 -
2021 (v1)Publication
The formation of neutrophil extracellular traps (NETs) is a strategy utilized by neutrophils for capturing infective agents. Extracellular traps consist in a physical net made of DNA and intracellular proteins externalized from neutrophils, where bacteria and viruses are entrapped and killed by proteolysis. A complex series of events...
Uploaded on: October 11, 2023 -
2021 (v1)Publication
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Uploaded on: April 14, 2023