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ANGELINI , Giovanna

Last name: ANGELINI

First name: Giovanna

2018 (v1)

Publication

Metadata-only

Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma

PATRONE, SERENA Maric, Irena RUTIGLIANI, MARIANGELA

Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual...

Uploaded on: April 14, 2023
2016 (v1)

Publication

Metadata-only

Analysis of the Expression and Single-Nucleotide Variant Frequencies of the Butyrophilin-like 2 Gene in Patients With Uveal Melanoma

AMARO, ADRIANA AGNESE Parodi, Federica Diedrich, Konrad

IMPORTANCE Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) with an otherwise high risk of metastasis conferred by chromosome 3 monosomy. Chromosome 6p contains several members of the B7 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is associated with...

Uploaded on: April 14, 2023