APARICIO SOTO , Marina

El lupus eritematoso sistémico (LES) es una enfermedad autoinmune inflamatoria crónica que puede afectar a múltiples órganos, provocando un deterioro progresivo que afecta a la calidad de vida de los pacientes. En la actualidad no se dispone de una terapia efectiva y eficaz para el LES, y tanto la propia enfermedad como sus tratamientos...

Extra virgin olive oil (EVOO) is obtained from the fruit of the olive tree Olea europaea L. Phenolic compounds present in EVOO have recognized anti-oxidant and anti-inflammatory properties. However, the activity of the total phenolic fraction extracted from EVOO and the action mechanisms involved are not well defined. The present study was...

Primary human keratinocytes are pretreated with HTy-Ac or HTy for 30 min and stimulated with IL-1β or Toll-like receptor 3 ligand (TLR3-l). Thymic stromal lymphopoietin (TSLP), measured by ELISA, is attenuated by both polyphenols in a dose-dependent manner. The expression of several inflammation-related genes, including distinct TSLP isoforms...

Scope:Squalene is a polyunsaturated triterpene, which has exhibited anticancer and antioxidantactivities among others. We investigated dietary squalene supplementation effect on an acutecolitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice.Methods and results:Mice were fed from weaning with squalene at 0.02% and 0.1%. After4...

Squalene is a natural triterpene consumed as an integral part of the human diet. Increasing evidence demonstrates that squalene has antioxidant, cardioprotective and anti-carcinogenic activities. Nevertheless, its anti-inflammatory properties remain unclear. The effects of squalene on lipopolysaccharide (LPS)-mediated inflammatory response in...

El objeto de la invención se centra en la síntesis por dos rutas alternativas del (3,4-dihidroxifenil)glicol (6), producto natural presente en el olivo, y en la síntesis de (3,4-dihidroxifenil)diacilglicoles (12). Tanto (6) como (12) son útiles como antiinflamatorios no esteroideos. De igual manera, los alcanoatos de hidroxitirosilo y diversos...