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ARATHI , Bangalore Prabhashankar

Last name: ARATHI

First name: Bangalore Prabhashankar

2022 (v1)

Publication

Metadata-only

Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling

Mishra, Sneha Cosentino, Claudia Tamta, Ankit Kumar

Chronic stress induces skeletal muscle atrophy via upregulation of glucocorticoid levels. Here, the authors show that SIRT6 transcriptionally regulates glucocorticoid-induced muscle atrophy by modulating IGF/PI3K/AKT signalling.Chronic activation of stress hormones such as glucocorticoids leads to skeletal muscle wasting in mammals. However,...

Uploaded on: February 4, 2024