ARGUEL , Marie-Jeanne

BACKGROUND: Brain-expressed genes that were created in primate lineage represent obvious candidates to investigate molecular mechanisms that contributed to neural reorganization and emergence of new behavioural functions in Homo sapiens. PMCHL1 arose from retroposition of a pro-melanin-concentrating hormone (PMCH) antisense mRNA on the...

The Mediterranean region is undergoing an increase in the frequency and intensity of extreme rainfall events, resulting in terrestrial runoffs that can affect aquatic environments in coastal regions. The goal of this study was to investigate the effects of terrestrial runoff on natural coastal planktonic assemblages. For this purpose, an in...

AbstractIn chordates, the central nervous system arises from precursors that have distinct developmental andtranscriptional trajectories. Anterior nervous systems are ontogenically associated with ectodermallineages while posterior nervous systems are associated with mesoderm. Taking advantage of the welldocumentedcell lineage of ascidian...

Background: Others and we have shown that T cells have an important role in hippocampal synaptic plasticity, including neurogenesis in the dentate gyrus, spinogenesis, and gluta-matergic synaptic function in the CA of the hippocampus. Hippocampus plasticity is particularly involved in the brain effects of the enriched environment (EE), and...

Cell response variability is a starting point in cancer drug resistance that has been difficult to analyze because the tolerant cell states are short lived. Here, we present fate-seq, an approach to isolate single cells in their transient states of drug sensitivity or tolerance before profiling. The drug response is predicted in live cells,...

Cell response variability is a starting point in cancer drug resistance that has been difficult to analyze because the tolerant cell states are short lived. Here, we present fate-seq, an approach to isolate single cells in their transient states of drug sensitivity or tolerance before profiling. The drug response is predicted in live cells,...

International audience

The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and basal cells, ensures proper mucociliary function and can regenerate in response to assaults. In chronic airway diseases, defective repair leads to tissue remodeling. Delineating key drivers of differentiation dynamics can help understand how normal or...

International audience

Highlights d Fate-seq links the drug response of a single cell to its own transcriptomic profile d Fate-seq recovers variable cell decision information from unstructured variability d It identifies molecular factors causing the intrinsic resistance to cancer drugs d A TRAIL therapeutic efficacy profile is performed in HeLa cells as proof of concept

Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T...

National audience

International audience

The presymptomatic phase of Parkinson's disease (PD) is now recognized as a prodromal phase, with compensatory mechanism masking its progression and non-motor early manifestations, such as depression, cognitive disturbances and apathy. Those mechanisms were thought to be strictly dopamine-mediated until recent advances have shed light upon...

International audience

Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T...