ARIAS-ARAGÓN , Francisco

La enfermedad de Alzheimer (AD) es una enfermedad neurodegenerativa asociada con el envejecimiento caracterizada por un deterioro progresivo de la memoria. La pérdida de la función sináptica es un factor temprano que correlaciona con la progresión de la enfermedad, indicando que alteraciones en la función sináptica contribuyen a los mecanismos...

Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the leading cause of familial Alzheimer's disease (fAD). However, the PS/gamma-secretase substrates relevant for the neuronal...

Alzheimer's disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequences of a sustained reduction of Nlgn1 are unknown. Here, we generated a knockin mouse that reproduces the...