The goal of this study was to identify new compounds from venoms able to modulate sperm physiology and more particularly sperm motility. For this purpose, we screened the effects of 16 snake venoms cleared of molecules higher than 15 kDa on sperm motility. Venoms rich in neurotoxins like those from Oxyuranus scutellatus scutellatus or Daboia...
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July 2010 (v1)Journal articleUploaded on: December 3, 2022
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October 2011 (v1)Journal article
Different mammalian secreted phospholipases A(2) (sPLA(2) s) are expressed in male reproductive organs and/or in sperm cells but their cellular functions are still not fully characterized. Because several reports indicate a link between cellular lipids and sperm motility, we have investigated the effect of mouse group IIA, IID, IIE, V, and X...
Uploaded on: December 4, 2022 -
June 2019 (v1)Journal article
Assisted reproductive technologies (ART) are widely used for both humans and domestic animals. In bovine species, in vitro embryo production is increasingly used and significant efforts are being made to optimize media and culture conditions. Phospholipase A2 (PLA2) are lipolytic enzymes that hydrolyze glycerophospholipids to produce free fatty...
Uploaded on: December 4, 2022 -
July 2022 (v1)Journal article
The group X secreted phospholipase A2 (PLA2G10) is present at high levels in mouse sperm acrosome. The enzyme is secreted during capacitation and amplifies the acrosome reaction and its own secretion via an autocrine loop. PLA2G10 also improves the rate of fertilization. In in vitro fertilization (IVF) experiments, sperm from Pla2g10-deficient...
Uploaded on: December 4, 2022 -
2022 (v1)Journal article
The group X secreted phospholipase A2 (PLA2G10) is present at high levels in mouse sperm acrosome. The enzyme is secreted during capacitation and amplifies the acrosome reaction and its own secretion via an autocrine loop. PLA2G10 also improves the rate of fertilization. In in vitro fertilization (IVF) experiments, sperm from Pla2g10-deficient...
Uploaded on: February 22, 2023 -
September 12, 2024 (v1)Journal article
3D reconstructions after tomographic imaging often suffer from elongation artifacts due to the limited-angle acquisitions. Retrieving the original 3D shape is not an easy task, mainly due to the intrinsic morphological changes that biological objects undergo during their development. Here we present to the best of our knowledge a novel approach...
Uploaded on: October 29, 2024 -
May 3, 2010 (v1)Journal article
Ejaculated mammalian sperm must undergo a maturation process called capacitation before they are able to fertilize an egg. Several studies have suggested a role for members of the secreted phospholipase A2 (sPLA2) family in capacitation, acrosome reaction (AR), and fertilization, but the molecular nature of these enzymes and their specific...
Uploaded on: December 3, 2022 -
September 12, 2012 (v1)Journal article
Calcium current through voltage-gated calcium channels (VGCC) controls gene expression. Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription. Electrical activity induces Cacnb4 association to Ppp2r5d, a regulatory subunit of PP2A phosphatase, followed by (i)...
Uploaded on: December 3, 2022