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ARSIC , Nikola

Last name: ARSIC

First name: Nikola

2015 (v1)

Journal article

Metadata-only

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Arsic, Nikola Gadea, Gilles Lagerqvist, Ebba Louise

Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that D133p53b, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. D133p53b stimulated the expression of the key pluripotency factors SOX2, OCT3/4, and NANOG. Similarly, in...

Uploaded on: February 28, 2023