AVELLA , Martine

Labex SIGNALIFEExcellence in Nice at the service of cell signalling in life sciencesCreated in 2012 as part of the «Investissements d'Avenir» programme, the «Labex SIGNALIFE» Laboratory of Excellence is specialised in cell signalling in the life sciences. Thanks to their high level of excellence, its research teams contribute to improving our...

In the present study, we characterized a STAS-domain amino acid mutation of SLC26A9 having a significant impact on ion transport. We focused on the sole conserved L- leucine residue of the STAS domain identified among SLC26 members. We therefore characterized the L683P mutation of SLC26A9 in Xenopus oocytes by monitoring the protein functional...

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We investigated the possible functional- and physical protein-interactions between two airway Cl(-) channels, SLC26A9 and CFTR. Bronchial CFBE41o-cell lines expressing CFTR(WT) or CFTR(DeltaF508) were transduced with SLC26A9. Immunoblots identified a migrating band corresponding to SLC26A9 present in whole cell lysates as on apical membrane of...