AWINA , Hala

Fas is a transmembrane cell death receptor mostly known for its function in inducing cell death through apoptosis, but it is also recognized to be implicated in a wide range of non-death functions in various cell types and contexts. The disequilibrium between cell death and survival signals due to defective apoptosis is a key factor in...

Finely tuned regulation of epithelial cell death maintains tissue integrity and homeostasis. At the cellular level, life and death decisions are controlled by environmental stimuli such as the activation of death receptors. We show that cell polarity and adherens junction formation prevent proapoptotic signals emanating from the Fas death...