A

M

AYYOUB , Maha

Last name: AYYOUB

First name: Maha

May 9, 2023 (v1)

Publication

Metadata-only

TNF plasma levels in advanced melanoma patients treated with immune checkpoint inhibitors: results from the MELANFα clinical study.

Virazels, Mathieu Lusque, Amélie Filleron, Thomas

Resistance mechanisms to immune checkpoint inhibitors (ICI) in cancer patients are not fully understood and predictive biomarkers are lacking. TNF is a pleiotropic cytokine that can be detrimental in cancer and TNF blockade potentiates ICI efficacy in preclinical models. MELANFα (NCT03348891) is a translational proof-of-concept, open-label,...

Uploaded on: April 5, 2025