AZPEITIA , Eugenio

This chapter presents models of the processes involved in floral initiation and development. It begins by briefy presenting models of hormonal transport. The focus is on two key aspects of floral development, namely floral initiation, due to the periodic local accumulation of auxin (a plant hormone) near the plant apex, and the genetic...

In this chapter we present models of processes involved in the initiation and development of a flower. In the first section, we briefly present models of hormonal transport. We focus on two key aspects of flower development, namely the initiation, due to the periodic local accumulation of auxin (a plant hormone) near at the plant apex, and the...

Boolean networks are important models of biochemical systems, located at the high end of the abstraction spectrum. A number of Boolean gene networks have been inferred following essentially the same method. Such a method first considers experimental data for a typically underdetermined "regulation" graph. Next, Boolean networks are inferred by...

The study of the concerted action of hormones and transcription factors is fundamental to understand cell differentiation and pattern formation during organ development. The root apical meristem of Arabidopsis thaliana is a useful model to address this. It has a stem cell niche near its tip conformed of a quiescent organizer and stem or initial...

Erratum: The combination of the functionalities of feedback circuits is determinant for the attractors' number and size in pathway-like Boolean networks (vol 7, 42023, 2017)

Molecular regulation was initially assumed to follow both a unidirectional and a hierarchical organization forming pathways. Regulatory processes, however, form highly interlinked networks with non-hierarchical and non-unidirectional structures that contain statistically overrepresented circuits or motifs. Here, we analyze the behavior of...

BACKGROUND:The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damage, normal and FA cells inhibit the cell cycle progression, until the G2/M checkpoint is turned off by the checkpoint recovery,...