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BÖSSER , Susanne

Last name: BÖSSER

First name: Susanne

November 10, 2004 (v1)

Journal article

Metadata-only

Transgenic overexpression of a dominant negative mutant of FADD that, although counterselected during tumor progression, cooperates in L-myc-induced tumorigenesis.

Hueber, Anne-Odile Bösser, Susanne Zörnig, Martin

Activation of the so-called death receptors, e.g., CD95/Fas/Apo-1, is a potent stimulus to trigger apoptosis. Overexpression of the C-terminal FADD deletion mutant FADD-DN blocks death receptor-induced apoptosis, but despite this antiapoptotic activity, lck FADD-DN transgenic mice do not develop lymphomas. To analyze whether functional...

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