BAGNASCO , Diego

Introduzione L'asma è una delle malattie respiratorie croniche tra le più comuni in tutto il mondo. Si stima che una percentuale di pazienti tra i 5 e i 10% sia affetta da una forma di asma grave, spesso non completamente controllata dalla terapia inalatoria, ma solo da una aggiunta cronica o da al bisogno di corticosteroidi sistemici. Nel...

PURPOSE OF REVIEW: Human eosinophils were first identified and named by Paul Ehrlich in 1879 on the basis of the cellʼs granular uptake of eosin. Although eosinophils represent approximately 1% of peripheral blood leukocytes, they have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophils and their mediators...

Purpose of review This article realizes an overview on the world of biological and biosimilar drugs in allergic and immunologic diseases' treatment strategies. We started talking about the history of asthma treatment's progresses, continuing to daily biological therapies, concluding with the economic point of view. Recent findings Nowadays, the...

Objective: Allergen-specific immunotherapy (AIT) in its subcutaneous and sublingual forms is currently a well-established and experimentally supported treatment for respiratory allergy and hymenoptera venom allergy. There have been advances in its use linked strictly to the advancement in the knowledge of the molecular mechanisms of allergy,...

Although different phenotypes of severe asthma can be identified, all are characterized by common symptoms. Due to their heterogeneity, they exhibit differences in pathogenesis, etiology and clinical responses to therapeutic approaches. The identification of distinct molecular phenotypes to define severe asthmatic patients will allow us to...