BALDINI , Francesca

Obesity is a condition characterized by an excessive accumulation of body fat, especially at the visceral level, which causes serious damage to health. Obesity is caused, in most cases, by unhealthy lifestyles (on the one hand, a high-calorie diet, and on the other, reduced or no physical activity). From an etiological point of view obesity is...

To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular model of hepatic steatosis.

PURPOSE: Phenolic compounds (PC) of virgin olive oil exert several biochemical and pharmacological beneficial effects. Some dietary PC seem to prevent/improve obesity and metabolic-related disorders such as non-alcoholic fatty liver disease (NAFLD). We investigated the possible effects of PC extracted from olive pomace (PEOP) and of the main...

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality. Oxidative stress and release of pro-in ammatory cytokines, such as tumor necrosis factor α (TNFα), are major consequences of hepatic lipid overload, which can contribute to progression of NAFLD to non-alcoholic steatohepatitis (NASH). Also,...