1995 (v1)
Publication
No description
Uploaded on: April 14, 2023
B
G
BELLESE , Grazia
Last name: BELLESE
First name: Grazia
Email: bgrazia@unige.it
Institution: UNIGE
Links
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2016 (v1)PublicationIdentification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells
The receptor tyrosine kinase ERBB2 interacts with HSP90 and is overexpressed in aggressive breast cancers.Therapeutic HSP90 inhibitors, i.e. Geldanamycin (GA), target ERBB2 to degradation. We have previously shown that HSP90 is responsible for the missorting of recycling ERBB2 to degradation compartments. In this study, we used biochemical,...
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1997 (v1)Publication
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2016 (v1)Publication
Background Carnosic acid (CA) is a diterpenoid found in Rosmarinus officinalis L. and Salvia officinalis L. as well as in many other Lamiaceae. This compound is reported to have antioxidant and antimicrobial properties. In addition, a number of reports showed that CA has a cytotoxic activity toward several cancer cell lines. Purpose The aim of...
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2017 (v1)Publication
active orphan receptor. Upon ligand binding and activation, ERBB receptors form homo- or hetero-dimers with the other family members, including ERBB2, promoting an intracellular signaling cascade. ERBB2 is the preferred dimerization partner and ERBB2 heterodimers signaling is stronger and longer acting compared to heterodimers between other...
Uploaded on: April 14, 2023