BONAVENTURA , Aldo

Objectives. To (i) determine the formation of the NLRP3 inflammasome in the pathogenesis of pericarditis and (ii) recreate pericardial inflammation in mice with a toll-like-receptor-2/inflammasome inducer and assess the effect of anti-inflammatory drugs on inflammasome-mediated disease. Background. Acute pericarditis is typically responsive to...

Hepatitis C virus (HCV) affects 3% of the world population. It represents the main cause of chronic liver disease and is responsible for extra-hepatic complications, such as type 2 diabetes and cardiovascular diseases. HCV includes 7 genotypes differing in the nucleotide sequence variability, the geographic distribution, the rates of viral...

In the last few decades, the recommended treatment for coronary artery disease has been dramatically improved by percutaneous coronary intervention (PCI) and the use of balloon catheters, bare metal stents (BMSs), and drug-eluting stents (DESs). Catheter balloons were burdened by acute vessel occlusion or target-lesion re-stenosis. BMSs greatly...

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BACKGROUND: Myocardial infarction is strictly linked to atherosclerosis. Beyond the mechanical narrowing of coronary vessels lumen, during MI a great burden of inflammation is carried out. One of the crucial events is represented by the ischemia/reperfusion injury, a complex event involving inflammatory cells (such as neutrophils, platelets,...

Prevalence of type 2 diabetes mellitus (T2DM) is increasing all over the world. Targeting good glycemic control is fundamental to avoid the complications of diabetes strictly linked to hyperglycemia. This narrative review is based on the material searched for and obtained via PubMed up to April 2015. The search terms we used were:...

INTRODUCTION: Acute ischemic stroke (AIS) represents a major cause of death and disability all over the world. The recommended therapy aims at dissolving the clot to re-establish quickly the blood flow to the brain and reduce neuronal injury. Intravenous administration of recombinant tissue-type plasminogen activator (rt-PA) is clinically used...

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