BORILE , Silvia

Proteus mirabilis prosthetic valve endocarditis is a rare and life-threatening condition not yet reported on tricuspid bioprostheses. We report a cas of a 43-year old woman, a heroin-user, presented with a giant vegetation extended the tricuspid valve prosthesis to the pulmonary artery.

Background and Purpose: 5-fluorouracil (5FU) and its prodrug, capecitabine, can damage endothelial cells, whilst endothelial integrity is preserved by glucagon-like peptide 1 (GLP-1). Here, we studied the effect of 5FU on endothelial senescence and whether GLP-1 antagonizes it. Experimental Approach: EA.hy926 cells were exposed to 5FU or sera...