B

A

BRIZZOLARA , Antonella

Last name: BRIZZOLARA

First name: Antonella

2014 (v1)

Publication

Metadata-only

Recombinant IL-21 and anti-CD4 antibodies cooperate in syngeneic neuroblastoma immunotherapy and mediate long-lasting immunity

RIGO, VALENTINA ORENGO, ANNA MARIA BRIZZOLARA, ANTONELLA

IL-21 is an immune-enhancing cytokine, which showed promising results in cancer immunotherapy. We previously observed that the administration of anti-CD4 cell-depleting antibody strongly enhanced the anti-tumor effects of an IL-21-engineered neuroblastoma (NB) cell vaccine. Here, we studied the therapeutic effects of a combination of...

Uploaded on: April 14, 2023
2017 (v1)

Publication

Metadata-only

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells

PENNA, ILARIA GIGONI, ARIANNA COSTA, DELFINA

We recently reported the in vitro over-expression of 45A, a RNA polymerase IIItranscribed non-coding (nc)RNA, that perturbs the intracellular content of FE65L1 affecting cell proliferation rate, short-term response to genotoxic stress, substrate adhesion capacity and, ultimately, increasing the tumorigenic potential of human neuroblastoma...

Uploaded on: April 14, 2023