2013 (v1)
Publication
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2015 (v1)Publication
This study was aimed to standardize the technique for counting monosodium urate (MSU) crystals in the synovial fluid (SF) of patients with gout. A total of 52 SF specimens were examined under a polarized light microscope. The amount of SF ranged between 0.1 and 45 mL (median 3 mL). MSU crystals were counted in four areas with the same size at...
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2013 (v1)Publication
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2011 (v1)Publication
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1999 (v1)Publication
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2010 (v1)Publication
To investigate the effects of 17beta-estradiol (E2) on extracellular matrix (ECM) protein synthesis (collagen type I, fibronectin, and laminin) using cultures of normal and scleroderma (SSc) skin fibroblasts. Primary fibroblasts cultures, obtained from skin biopsies of six female voluntary subjects and three female SSc patients, were treated...
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2015 (v1)Publication
Previous studies have reported the presence of CD86 (B7.2) costimulatory molecule on endothelial cells (ECs) and recent data have shown that CTLA4-Ig (abatacept), used as a biological agent in rheumatoid arthritis, interacts with CD86 expressed on different cells involved in synovitis. Therefore, the effects of CTLA4-Ig/CD86 interaction on...
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2012 (v1)Publication
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2017 (v1)Publication
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2000 (v1)Publication
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2017 (v1)Publication
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2016 (v1)Publication
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2015 (v1)Publication
To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts.
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2010 (v1)PublicationEstrogens interfere with leflunomide modulation of cytokine production by human activated monocytes.
Rheumatoid arthritis (RA) prevalence is greater in females than in males, supporting estrogens as modulators of immune response. Leflunomide (LEF) is employed in the RA treatment. We studied the combinatory effects of LEF active metabolite A77 1726 (LEF-M) and 17beta-estradiol (E2) on inflammatory cytokine production by cultured macrophages...
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2009 (v1)Publication
Clinical and experimental evidence indicates that rheumatoid arthritis prevalence is greater in females than in males, and supports a role for estrogens as modulators of the immune response. Immunocytochemistry (ICC) showed that the antiproliferative drug Leflunomide (LEF) is successfully employed in rheumatoid arthritis. In this study we...
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1999 (v1)Publication
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Uploaded on: December 5, 2022