2013 (v1)
Publication
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B
C
BRULLO , Chiara
Last name: BRULLO
First name: Chiara
Email: chiara.brullo@unige.it
Institution: UNIGE
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2002 (v1)Publication
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2014 (v1)Publication
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2013 (v1)Publication
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2001 (v1)Publication
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2005 (v1)Publication
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2008 (v1)Publication
A review. FLT3 is a tyrosine kinase (TK), member of the class III TK receptor family, normally expressed in hematopoietic, immune and neural systems, also playing an important role in the pathogenesis of acute leukemias, particularly acute myeloid leukemia (AML), where it is present in constitutively activated mutated forms, correlated with...
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2010 (v1)Publication
Resistance to the Bcr-Abl inhibitors approved for the treatment of chronic myeloid leukaemia (CML) may arise from different mechanisms, including Bcr-Abl amino acid mutations, gene amplification and mechanisms independent of Bcr-Abl. The T315I mutation at the gatekeeper residue is very frequent in advanced phases of the disease and is one of...
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2010 (v1)Publication
A review. C-Src and Bcr-Abl are 2 non-receptor or cytoplasmic tyrosine kinases (TKs) that play important roles in the development of solid and hematol. malignancies. Indeed, Src is overexpressed or hyperactivated in a variety of solid tumors, while Bcr-Abl is the causative agent of chronic myeloid leukemia (CML), where Src is also involved. ...
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2014 (v1)Publication
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2012 (v1)Publication
Anomalous activation of neutrophil recruitment is one of the causes of many inflammatory diseases. The chemoattractants N-formyl-methionyl-leucyl-phenylalanine (fMLP), and interleukine 8 (IL8) play a pivotal role in neutrophil chemotaxis regulation in the latter and early stages, respectively, probably by two independent mechanisms. We reported...
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2012 (v1)Publication
The recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of these agents and the importance of the research in the field of angiogenesis inhibitors for future oncologic therapy. In this Perspective we briefly report the inhibitors that are in clinical use, while we dedicate two wider sections to the compounds...
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2014 (v1)Publication
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2007 (v1)Publication
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2008 (v1)Publication
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2012 (v1)Publication
C-Src and Bcr-Abl are two cytoplasmatic tyrosine kinases (TKs) involved in the development of malignancies. In particular, Bcr-Abl is the etiol. agent of chronic myeloid leukemia, where Src is also involved; the latter is hyperactivated in several solid tumors. Because of the structural homol. between Src and Abl, several compds. originally...
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2008 (v1)Publication
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Uploaded on: March 31, 2023