BRUZZESE D.

The aim of this study was to examine the homocysteine effect on phospholipase C gamma 2 (PLC gamma 2) activation and to investigate the signaling pathway involved. We found that homocysteine stimulated the tyrosine phosphorylation and activation of platelet PLC gamma 2. The tyrosine kinases p60src and p72syk appeared to be involved upstream....

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Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could play a very important role....

The synthesis and in vitro antiplatelet activity significant data of coumarin derivatives 5i-x and quinolin- 2(1H)-one derivatives 22a,b, as well as the corresponding structure-activity relationships are described. The recently reported 8-methyl-4-(1-piperazinyl)-7-(3-pyridylmethoxy)coumarin 5f and its potent 7-(2- morpholinoethoxy)-substituted...