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2013 (v1)PublicationUploaded on: April 14, 2023
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2015 (v1)Publication
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2008 (v1)Publication
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2015 (v1)Publication
Sirtuins are NAD(+)-dependent deacetylases with several biological roles in DNA regulation, genomic stability, metabolism, longevity and immune cell functions. Numerous disease conditions are linked to sirtuins including metabolic disorders, inflammatory and autoimmune processes and cancer. Although few specific small molecule modulators have...
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2011 (v1)Publication
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2005 (v1)Publication
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2001 (v1)Publication
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2006 (v1)Publication
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2004 (v1)Publication
CD38, a multifunctional enzyme, generates two potent Ca2+-releasing signal metabolites, cyclic ADP-ribose (cADPR) and NAADP+, thereby upmodulating many important Ca2+-mediated cell functions. A topological paradox has long been recognized, as CD38 is an ectoenzyme, or an intravesicularly located enzyme in subcellular membrane vesicles,...
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1998 (v1)Publication
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2003 (v1)Publication
Cyclic ADP-ribose (cADPR), a universal calcium mobilizer from intracellular stores, was recently demonstrated to stimulate proliferation of various cell types. The role of cADPR in a specific process of monocyte- and plasma-mediated activation of T-lymphocytes by lipopolysaccharide (LPS) was addressed using human mononuclear cells from...
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2003 (v1)Publication
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2006 (v1)Publication
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2006 (v1)Publication
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2002 (v1)Publication
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1998 (v1)Publication
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