BALASSE , Laure

A polydisperse scattering model adapted for concentrated medium, namely the polydisperse structure factor model, was examined in order to explain the backscatter coefficients (BSCs) measured from packed cell samples undergoing cell death. Cell samples were scanned using high-frequency ultrasound in the 10-42 MHz bandwidth. A parameter...

Quantitative UltraSound (QUS) techniques for determining the tissue microstructure are promising tools to detect and quantify cell death, and thus monitor the tumor response to therapy. Previous in vitro experimental studies suggested that the changes in the backscatter coefficient (BSC) during cell death were linked to the increase of the...

International audience

A scaling subtraction method was proposed to analyze the radio frequency data from cancer cell samples exposed to an anti-cancer drug and to estimate a nonlinear parameter. The nonlinear parameter was found to be well correlated (R2=0.62) to the percentage of dead cells in apoptosis and necrosis. The origin of the nonlinearity may be related to...